A couple, married for three years, had two abortions. Karyotype analysis results showed that the husband is the reciprocal translocation carrier, the karyotypes were 46, XY, t (3; 7) (q21; q22). The male’s translocation was inherited from his father; The female had a normal karyotype. The couple followed the doctor's advice to try PGT-SR detection. Researchers used PGH technology to detect spouses, male’s father and seven embryos at the same time. Through high-throughput whole genome chip technology combined with family haplotype linkage analysis, they finally obtained two normal embryos for implantation.
Preimplantation Genetic Testing For Structural Rearrangement
Based on whole genome SNP chip technology, PGT-SR can help identify embryos with the correct amount of chromosomal material that are most likely to lead to a successful pregnancy and healthy live birth. The three primary types of rearrangements we test for are: reciprocal translocations, Robertsonian translocations, and inversions.
Couples who experienced recurrent miscarriage or IVF failure due to chromosomal inversion
Couples who experienced recurrent miscarriage or IVF failure due to chromosomal reciprocal translation
Couples who experienced recurrent miscarriage or IVF failure due to Chromosomal robertsonian translocation
No pre-experiment, one test and analysis are required for testing
No need waste embryos, suitable for most genetic disease carrier families
Applicable to various chromosomes structural variations
Next-generation sequencing technology, increased 50% SNP site
Test report will be issued within 20 working days
Haplotype analysis model won national patent award